Figure: RUFY1 mediates early endosome to Golgi transport. (Human)¶
This figure illustrates the RUFY1-mediated early endosome to Golgi transport pathway in human cells. ARL8B (red) uses its GTPase activity to activate RUFY1 (green), which functions as a protein-macromolecule adaptor. RUFY1 then activates RAB4B and RAB14 (blue), which promote endosomal vesicle fusion. This process facilitates the transport of vesicles from the early endosome to the Golgi apparatus, a critical step in protein trafficking. All proteins are shown at their documented subcellular location in the early endosome membrane.
Feedback from AI on figure:
{"feedback":"The diagram clearly illustrates the RUFY1-mediated early endosome to Golgi transport pathway with an appropriate level of detail for a scientific journal figure. The use of color-coding makes it easy to distinguish between different protein types (GTPases vs adaptor proteins), and the directional arrows effectively show the sequence of molecular interactions. The addition of brief functional annotations for each protein enhances understanding without cluttering the image. The cellular compartments (early endosome and Golgi) are depicted with appropriate artistic styling that maintains scientific accuracy while being visually appealing. The diagram successfully captures the key elements from the GO-CAM model: ARL8B's GTPase activity activating RUFY1, RUFY1's adaptor function, and the roles of RAB4B and RAB14 in endosomal vesicle fusion leading to transport to the Golgi.","necessary_changes":null,"optional_changes":null}