Figure: MICA-NKG2D mediated NK cell cytotoxicity (Human)¶
Figure: MICA-NKG2D mediated NK cell cytotoxicity pathway. The diagram illustrates the molecular signaling cascade initiated when MICA on an endothelial cell surface binds to the NKG2D receptor (KLRK1) on a natural killer (NK) cell. This binding activates the HCST (DAP10) adaptor protein, which recruits downstream signaling molecules PIK3R1, GRB2, and VAV1 in the NK cell cytoplasm, ultimately triggering NK cell-mediated cytotoxicity. Proteins are shown as colored rectangles with their gene names (UniProt identifiers in parentheses in the legend), and arrows indicate the direction of signal transduction.
Feedback from AI on figure:
{"feedback":"This diagram effectively captures the MICA-NKG2D mediated NK cell cytotoxicity pathway with scientific accuracy and visual clarity. The illustration shows the key molecular interactions between an endothelial cell and an NK cell that lead to cytotoxicity, following journal figure conventions for Cell and Nature. The protein components (MICA, KLRK1, HCST, PIK3R1, GRB2, and VAV1) are clearly labeled with distinct colors, and directional arrows accurately represent the signaling flow. The comprehensive legend includes both protein names and their molecular functions, making this figure suitable for a scientific publication.","necessary_changes":null,"optional_changes":null}