Figure: Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human)¶
This figure illustrates the pathway controlling GABAAR clustering to GABAergic synapses by Gephyrin in human neurons. The process begins with the palmitoylation of Gephyrin (GPHN) by ZDHHC12 at the Golgi membrane, an essential post-translational modification that enables Gephyrin's subsequent functions. Palmitoylated Gephyrin is transported to the postsynaptic membrane where it acts as a scaffolding protein, clustering GABAA receptors at inhibitory synapses.
The GABAA receptor complex is composed of several subunits: GABRA1 (α1), GABRB2 (β2), GABRB3 (β3), and GABRG2 (γ2), which together form a pentameric chloride ion channel. When GABA (gamma-aminobutyric acid) binds to these receptors, it triggers the opening of the chloride channel, allowing chloride ions to flow into the cell, resulting in hyperpolarization and inhibitory synaptic transmission.
This molecular pathway is critical for proper inhibitory neurotransmission in the brain, and dysfunction in this process has been implicated in various neurological disorders including epilepsy, anxiety disorders, and neurodevelopmental conditions.
Feedback from AI on figure:
{"feedback":"The final diagram effectively illustrates the control of GABAAR clustering by Gephyrin at GABAergic synapses with excellent clarity and scientific accuracy. All major components of the pathway are properly represented, including the palmitoylation of Gephyrin by ZDHHC12 in the Golgi apparatus, Gephyrin's role in receptor clustering at the postsynaptic membrane, and the functional GABAAR complex with its distinct subunits. The drawing shows good use of color coding, appropriate labeling, and clear visual hierarchy that helps guide the viewer through the biological process. The figure maintains a professional style suitable for publication in journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}