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Figure: TREM2 activated by APOE. (Human)

id: gomodel:6606056e00000859

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This diagram illustrates the TREM2 activation pathway by APOE in microglial cells, a process important in neurodegenerative diseases. The pathway involves:

  1. APOE (red circle): In the extracellular space, functions as a ligand
  2. TREM2 (blue rectangle): A transmembrane receptor on microglia that recognizes APOE
  3. TYROBP/DAP12 (green rectangle): An adaptor protein recruited by activated TREM2
  4. SYK (purple rectangle): A tyrosine kinase activated by TYROBP

The pathway represents two biological processes: - Cellular response to lipoprotein particle stimulus (GO:0071402) - Cellular response to amyloid-beta (GO:1904646)

Subcellular locations are clearly demarcated: extracellular space, plasma membrane, and cytoplasm. Arrows indicate the direction of activation flow in the signaling cascade.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the TREM2 activation pathway by APOE in microglial cells with excellent clarity and scientific accuracy. The improved version incorporates all previous feedback, with larger text for better readability, clear directional arrows showing the activation pathway, and a comprehensive legend explaining the color-coding and molecular components. The addition of an explanatory note provides valuable context about the pathway's role in neurodegenerative diseases. The cellular compartments are well-defined, and the molecular interactions between APOE, TREM2, TYROBP, and SYK are clearly represented with appropriate GO terms and UniProt identifiers. The overall layout and design are consistent with publication-quality figures suitable for journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}