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Figure: CD72 and BCR co-stimulation by sn/RNP self antigen (Human)

id: gomodel:6606056e00002011

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This illustration depicts the CD72 and BCR co-stimulation pathway in human B cells triggered by sn/RNP self antigen. The diagram shows a simplified B cell with plasma membrane (GO:0005886) and cytoplasm (GO:0005737). Key components include:

  1. sn/RNP self antigen binding to both the B cell receptor complex (CD79A/CD79B) (GO:0019815) and CD72 receptor (UniProtKB:P21854)
  2. BCR activation leading to LYN kinase (UniProtKB:P07948) activation with protein tyrosine kinase activity (GO:0004713)
  3. LYN phosphorylating CD72, which then recruits PTPN6/SHP-1 (UniProtKB:P29350) with protein tyrosine phosphatase activity (GO:0004725)
  4. PTPN6 triggering negative regulation of B cell receptor signaling pathway (GO:0050859)
  5. This pathway ultimately contributing to B cell homeostasis (GO:0001782)

All components and interactions are directly derived from the GO-CAM model, illustrating how CD72 co-stimulation functions to regulate BCR signaling and maintain B cell homeostasis.

Feedback from AI on figure:

{"feedback":"The diagram effectively communicates the CD72 and BCR co-stimulation pathway triggered by sn/RNP self antigen in human B cells. The illustration clearly depicts the cellular compartments (extracellular space, plasma membrane, cytoplasm) and shows the sequential flow of signaling from receptor binding to downstream effects. The use of distinct colors for different components aids in visual recognition, while the labeled arrows clearly indicate the nature of interactions between molecules. All key components from the GO-CAM model are accurately represented, including the B cell receptor complex (CD79A/CD79B), CD72, LYN kinase, and PTPN6 phosphatase. The diagram maintains scientific accuracy while presenting the information in a visually appealing format suitable for a journal publication.","necessary_changes":null,"optional_changes":null}