Figure: The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human).¶
This diagram illustrates the human CRL5(ASB9) complex-mediated pathway for ubiquitination and degradation of CKB (Creatine Kinase B). The pathway begins with RNF7 neddylation (green), which then joins with CUL5 (scaffold, red) and ASB9 (substrate adaptor, blue) to form the CRL5(ASB9) E3 ligase complex (yellow). This complex, with assistance from ARIH2 (purple), targets CKB (pink) for ubiquitination (yellow circle), leading to its degradation by the 26S proteasome. CKB degradation regulates phosphocreatine biosynthesis (light green). GO terms are included to indicate the molecular functions of each component.
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively illustrates the CRL5(ASB9) complex mediating ubiquitination and degradation of CKB in humans. The linear layout provides clear visualization of the sequential steps from neddylation through complex formation, ubiquitination, and finally degradation. The color coding system with accompanying legend helps distinguish different components and processes within the pathway. Protein functions are well-annotated with their respective GO terms, and the arrows clearly indicate the direction of the process flow.","necessary_changes":null,"optional_changes":"Consider increasing the font size of GO terms for better readability, especially when viewing at a distance or in print format. Some text against colored backgrounds could benefit from improved contrast."}