Figure: The growth hormone receptor signaling pathway (Human).¶
The diagram illustrates the human growth hormone receptor signaling pathway (GO-CAM: 66187e4700001597). Growth hormone (GH1) in the extracellular space binds to its receptor (GHR) on the plasma membrane, activating JAK2 on the cytoplasmic side. This leads to STAT5B phosphorylation, its translocation to the nucleus, and subsequent DNA binding to regulate gene expression. Different colors highlight specific pathway components and their molecular functions: growth factor activity (GH1), receptor binding (GHR), tyrosine kinase activity (JAK2), and transcription factor activity (STAT5B). The diagram shows the spatial organization across cellular compartments: extracellular space, plasma membrane, cytoplasm, and nucleus.
Feedback from AI on figure:
{"feedback":"The diagram effectively captures the growth hormone receptor signaling pathway in humans, presenting the key components and their interactions in a clear, visually appealing manner. The color-coding system helps distinguish different proteins (GH1, GHR, JAK2, STAT5B) and their respective activities throughout the signaling cascade. The spatial organization accurately represents the cellular compartmentalization of the pathway, from extracellular signaling through membrane receptor binding to cytoplasmic signal transduction and nuclear translocation. The different arrow styles effectively distinguish between activation events and protein translocation. The legend provides comprehensive information about each component, including UniProtKB identifiers, making the diagram both scientifically accurate and visually informative, suitable for publication in high-impact journals.","necessary_changes":null,"optional_changes":null}