Figure: The erythropoietin-mediated signaling pathway (Human).¶
This figure depicts the erythropoietin-mediated signaling pathway (GO:0038162) in humans, which consists of four key stages:
Stage 1 (Red): Ligand Binding - Erythropoietin (EPO, P01588) in the extracellular space exhibits cytokine activity (GO:0005125) and binds to its receptor.
Stage 2 (Orange): Receptor Activation - The erythropoietin receptor (EPOR, P19235) embedded in the plasma membrane exhibits erythropoietin receptor activity (GO:0004900) and becomes activated upon EPO binding.
Stage 3 (Green): Signal Transduction - Janus kinase 2 (JAK2, O60674) located at the cytoplasmic side of the plasma membrane (GO:0031234) exhibits non-membrane spanning protein tyrosine kinase activity (GO:0004715) and phosphorylates Signal transducer and activator of transcription 5B (STAT5B, P51692).
Stage 4 (Purple): Transcription - Phosphorylated STAT5B translocates to the nucleus (GO:0005634) where it exhibits DNA-binding transcription factor activity (GO:0003700) to regulate gene expression.
This signaling cascade plays crucial roles in erythropoiesis, promoting red blood cell production and maturation.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the erythropoietin-mediated signaling pathway in a clear, visually appealing manner suitable for publication in high-impact journals like Cell or Nature. The pathway is logically structured with distinct cellular compartments and a clear flow of information from EPO binding to transcriptional activation. Each protein is appropriately labeled with both common names and UniProt identifiers, while molecular functions are identified with GO terms.\n\nThe color-coding system enhances clarity by visually distinguishing between the four key stages of the pathway: ligand binding (red), receptor activation (orange), signal transduction (green), and transcription (purple). The addition of a legend makes these distinctions explicit and helps readers quickly interpret the diagram.\n\nThe drawing maintains scientific accuracy while using appropriate artistic enhancements to emphasize important features of the pathway, such as the phosphorylation event and nuclear translocation. Cellular compartments are clearly delineated with appropriate gradients and textures to create depth and realism without sacrificing clarity.","necessary_changes":null,"optional_changes":null}