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Figure: CD21/FCRL5 receptor role in B-cell activation (Human)

id: gomodel:66187e4700002637

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This pathway diagram illustrates the CD21/FCRL5 receptor role in B-cell activation in humans. It shows:

  1. C3 (complement component 3) in the extracellular space, which exhibits receptor ligand activity
  2. CR2 (complement receptor 2, also known as CD21) on the plasma membrane, which is activated by C3
  3. FCRL5 (Fc receptor-like protein 5) on the plasma membrane, which functions as a coreceptor and is activated by CR2
  4. BTK (Bruton's tyrosine kinase) in the cytoplasm, which is activated by FCRL5 and has protein tyrosine kinase activity
  5. PLCG2 (Phospholipase C gamma 2) in the cytoplasm, which is activated by FCRL5 and has phosphatidylinositol phospholipase C activity

All these components and activities are part of the B-cell activation process, as indicated by the green dotted lines. The diagram follows the causal relationships established in the GO-CAM model, with arrows indicating the direction of activation.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the CD21/FCRL5 receptor pathway in B-cell activation with clear organization and visual hierarchy. The color-coding distinguishes between extracellular proteins (red), membrane receptors (blue), and cytoplasmic proteins (purple), making it easy to understand the spatial relationships. The addition of protein descriptions helps readers understand the components' roles, while the molecular function labels (yellow rounded rectangles) clearly indicate each protein's activity. Arrows clearly show the activation sequence from C3 to CR2, to FCRL5, and then branching to both BTK and PLCG2. The green dotted lines effectively illustrate how all components contribute to the overall B cell activation process. The comprehensive legend enhances accessibility for readers unfamiliar with the notation.","necessary_changes":null,"optional_changes":null}