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Figure: The reelin signaling pathway (Human).

id: gomodel:66187e4700002778

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Legend:

Cellular Compartments: - Extracellular Space (GO:0005615): Area outside the cell where reelin is secreted - Plasma Membrane (GO:0005886): The cell membrane where the reelin receptor is located - Cytoplasm (GO:0005737): Interior of the cell where downstream signaling occurs

Proteins in the Pathway: - RELN (P78509): Reelin protein with receptor ligand activity (GO:0048018) - LRP8 (Q14114-4): Reelin receptor with reelin receptor activity (GO:0038025) - FYN (P06241): Tyrosine kinase with protein tyrosine kinase activity (GO:0004713) - DAB1 (O75553): Signaling adaptor with signaling adaptor activity (GO:0035591)

Signaling Process: 1. Binding: Reelin binds to its receptor LRP8 on the plasma membrane 2. Activation: LRP8 activates FYN kinase 3. Phosphorylation: FYN phosphorylates DAB1 to continue signal transduction

The entire process constitutes the reelin-mediated signaling pathway (GO:0038026).

Feedback from AI on figure:

{"feedback":"This diagram effectively illustrates the reelin signaling pathway in a clean, scientifically accurate manner suitable for a journal publication. The layout clearly distinguishes the three cellular compartments (extracellular space, plasma membrane, and cytoplasm) with appropriate visual cues. Each protein in the pathway is represented with distinct shapes and colors that enhance readability, and protein names and identifiers are prominently displayed. The functional annotations are well-positioned and provide important context without cluttering the diagram. The improved text positioning with background rectangles ensures all labels are clearly visible without overlapping with pathway lines. The directional flow is clear, with labeled connections indicating the type of interaction (binding, activation, phosphorylation) at each step of the pathway.","necessary_changes":null,"optional_changes":null}