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Figure: IFNA1-CR2 role in B-cell ISGs induction (Human)

id: gomodel:66187e4700002881

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This figure illustrates the IFNA1-CR2 pathway involved in B-cell ISG induction in humans. The diagram shows the type I interferon signaling pathway with:

  1. IFNA1 (P01562) in the extracellular space exhibiting cytokine activity (GO:0005125)
  2. CR2 receptor (P20023) on the plasma membrane with transmembrane signaling receptor activity (GO:0004888)
  3. Two downstream effectors in the cytoplasm:
  4. MX1 (P20591) with GTPase activity (GO:0003924)
  5. EIF2AK2 (P19525) with kinase activity (GO:0016301)
  6. Both effectors contribute to the antiviral innate immune response (GO:0140374)

The causal relationships between components are indicated by arrows, with relationship ontology terms (RO:0002629, RO:0002407) labeling the specific relationships between molecules. The entire pathway operates as part of the type I interferon-mediated signaling pathway (GO:0060337).

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the IFNA1-CR2 pathway in B-cell ISG induction with clear compartmentalization (extracellular space and cytoplasm) and well-defined molecular interactions. Each protein is properly labeled with its identifier, and their respective molecular functions are indicated. The use of distinct colors for different functional categories enhances clarity, while the comprehensive legend explains all visual elements. The cellular context is well-represented with the plasma membrane clearly delineated, and the directional flow of signaling is apparent through the strategic use of arrows showing causal relationships.","necessary_changes":null,"optional_changes":null}