Skip to content

Figure: GDP-mannose biosynthetic process from glucose (Mouse)

id: gomodel:66187e4700003043

img

This diagram depicts the GDP-mannose biosynthetic process in mouse cytosol, following the pathway from glucose to GDP-mannose through five sequential enzymatic reactions:

  1. Phosphorylation: Hexokinase 1 (Hk1) converts glucose to glucose-6-phosphate
  2. Isomerization: Glucose-6-phosphate isomerase (Gpi1) converts glucose-6-phosphate to fructose-6-phosphate
  3. Isomerization: Mannose-6-phosphate isomerase (Mpi) converts fructose-6-phosphate to mannose-6-phosphate
  4. Phosphomutation: Phosphomannomutase (Pmm2) converts mannose-6-phosphate to mannose-1-phosphate
  5. Guanylyl transfer: Mannose-1-phosphate guanylyltransferase (Gmppb) uses GTP to convert mannose-1-phosphate to GDP-mannose, releasing pyrophosphate (PPi) as a by-product

Color coding: Blue circles represent substrates and intermediates, green circle shows the final product (GDP-mannose), red rectangles indicate enzymes, yellow circle shows the co-substrate (GTP), and pink circle indicates the by-product (PPi).

Feedback from AI on figure:

{"feedback":"This SVG diagram effectively illustrates the GDP-mannose biosynthetic pathway from glucose in mouse cytosol. The diagram employs professional styling suitable for a scientific journal like Cell or Nature, with clear organizational flow and appropriate labeling of all components. The use of color coding helps distinguish between different molecule types (substrates, enzymes, products), and the gradient-colored arrows effectively show the direction of reactions. The pathway steps are well-labeled with both the enzyme names and their functions, making the diagram informative even for viewers less familiar with this specific biochemical pathway.","necessary_changes":null,"optional_changes":"For publication in high-impact journals, consider adding supporting references or including enzyme EC numbers for more precise scientific annotation. Additionally, the pathway could be enhanced with ATP/ADP cofactors for the hexokinase reaction, though this would be considered an extension beyond the strict GO-CAM model provided."}