Figure: ubiquinone metabolic process (GO:0006743 )¶
The figure depicts the ubiquinone (Coenzyme Q10) metabolic process in fission yeast (Schizosaccharomyces pombe) as represented in a GO-CAM model. The pathway begins in the cytosol where spo9 and fps1 enzymes catalyze the formation of farnesyl diphosphate. This substrate enters the mitochondria where it is processed by a series of enzymes localized to the mitochondrial inner membrane. The dps1/dlp1 complex synthesizes decaprenyl diphosphate, which is then used by ppt1 to form a prenylated intermediate. Sequential modifications by coq6 (oxygenase), coq3 (O-methyltransferase), coq5 (C-methyltransferase), and coq7 (hydroxylase) convert this intermediate into Coenzyme Q10. The pathway is regulated by azr1 (a phosphatase) and the final product is transported by coq10 (a molecular carrier). Color coding distinguishes cytosolic enzymes (light green), mitochondrial enzymes (light purple), substrates (light blue), and the final product Coenzyme Q10 (orange).
Feedback from AI on figure:
{"feedback":"This drawing effectively visualizes the ubiquinone metabolic pathway in S. pombe with excellent clarity and scientific accuracy. The diagram follows the conventions of high-quality journal figures with clear cellular compartmentalization and proper enzyme positioning. The pathway flow is logical and easy to follow, with each enzyme clearly labeled with both its gene name and function. The color coding system enhances understanding of the different components, and the comprehensive legend provides valuable context for interpretation.","necessary_changes":null,"optional_changes":"For future iterations, consider adding small molecular structures for key intermediates in the pathway to further enhance the biochemical context."}