Figure: isoprenoid biosynthetic process (GO:0008299)¶
The SVG drawing depicts the isoprenoid biosynthetic pathway in Schizosaccharomyces pombe (fission yeast), showing the mevalonate pathway leading to farnesyl diphosphate synthesis and ultimately ergosterol biosynthesis. The pathway occurs across subcellular compartments, primarily in the cytosol (GO:0005829) with some reactions in the endoplasmic reticulum (GO:0005783).
Key enzymes are shown in red boxes: - erg10: Acetyl-CoA C-acetyltransferase - hcs1: Hydroxymethylglutaryl-CoA synthase - hmg1: HMG-CoA reductase - erg12: Mevalonate kinase - erg8: Phosphomevalonate kinase - mvd1: Diphosphomevalonate decarboxylase - idi1: Isopentenyl-diphosphate delta-isomerase - spo9: Dimethylallyltranstransferase/geranyltranstransferase (ER-localized) - fps1: Farnesyl diphosphate synthase - erg9: Squalene synthase
The pathway represents three main biological processes: 1. Mevalonate pathway (GO:0019287) 2. Farnesyl diphosphate biosynthesis (GO:0045337) 3. Ergosterol biosynthesis (GO:0006696)
Key isoprenoid intermediates include: - IPP (CHEBI:16584): Isopentenyl diphosphate - GDP (CHEBI:17211): Geranyl diphosphate - FPP (CHEBI:17407): Farnesyl diphosphate
The pathway diagram follows the standard conventions for metabolic pathway representation in journals like Cell or Nature, with metabolites shown as rounded rectangles and enzymes as smaller boxes. Dotted lines represent transport or multiple enzymatic steps.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the isoprenoid biosynthetic pathway in S. pombe with clear subcellular compartmentalization between cytosol and endoplasmic reticulum. The diagram appropriately represents all gene products from the GO-CAM model in their correct locations, with enzymes shown as red boxes and metabolites as rounded rectangles.\n\nThe flow of the pathway is logically arranged, starting with acetyl-CoA and proceeding through the mevalonate pathway to produce IPP, which is then converted to DMAPP. These precursors feed into the production of geranyl diphosphate (in the ER) and farnesyl diphosphate (in the cytosol), ultimately leading to ergosterol biosynthesis via squalene.\n\nThe addition of a color-coded legend helps clarify the meaning of different shapes and colors, while the increased font sizes improve readability. The image maintains the scientific accuracy of the GO-CAM while presenting it in a visually appealing format suitable for publication in high-impact journals.","necessary_changes":null,"optional_changes":null}