Figure: GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human).¶
This pathway diagram illustrates the molecular mechanism of GSDMD-mediated pyroptosis in human cells. The process begins with palmitoylation of GSDMD by two palmitoyltransferases (ZDHHC5 and ZDHHC9) in the cytosol. Palmitoylated GSDMD is then cleaved by caspase-1 (CASP1), releasing the N-terminal fragment. This N-terminal fragment binds to PI(4,5)P2 in the plasma membrane and oligomerizes to form wide pores, leading to membrane rupture and inflammatory pyroptotic cell death. This pathway highlights how post-translational modifications (palmitoylation) can regulate inflammatory cell death mechanisms.
Feedback from AI on figure:
{"feedback":"The diagram effectively communicates the process of GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promoting pyroptosis. The pathway is clearly laid out with directional arrows, making it easy to follow the sequence of events. The labels are well-spaced and the use of different colors for different proteins and processes enhances clarity. The added summary provides valuable context about the overall process of pyroptosis.","necessary_changes":null,"optional_changes":null}