Figure: Gsdmd palmitoylation by Zdhhc5 and Zdhhc9 promotes pyroptosis (Mouse)¶
This figure illustrates the molecular pathway of Gsdmd palmitoylation by Zdhhc5 and Zdhhc9 enzymes promoting pyroptosis in mice.
Key components: - Palmitoyl-transferases (ZDHHC5, ZDHHC9) in blue - GSDMD and its cleaved form in green - CASP4 protease in orange - NLRP3 inflammasome complex in yellow - Membrane pores shown as red channels
The pathway depicts how ZDHHC5 and ZDHHC9 palmitoylate GSDMD (GO:0019706), which is then cleaved by CASP4's cysteine-type endopeptidase activity (GO:0004197) in the cytosol (GO:0005829). Cleaved GSDMD binds phosphatidylinositol-4,5-bisphosphate (GO:0005546) at the plasma membrane (GO:0005886), forming wide pores (GO:0022829) that lead to pyroptotic cell death (GO:0141201). NLRP3 participates in this process through its signaling adaptor activity (GO:0035591) and inflammasome complex assembly (GO:0044546), positively regulating the pyroptotic inflammatory response (GO:0140639).
Feedback from AI on figure:
{"feedback":"The figure provides a clear and scientifically accurate representation of the Gsdmd palmitoylation pathway leading to pyroptosis. The color-coding, directional arrows, and labeled components effectively convey the sequence of biochemical events described in the GO-CAM model. The diagram maintains scientific rigor while presenting the information in a visually appealing format suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}