Figure: TRAIL/TRAILR1 interaction leading to apoptosis¶
The diagram illustrates the TRAIL/TRAILR1 pathway leading to apoptosis in human cells.
Key components: - TRAIL (TNFSF10): Cytokine in extracellular space with cytokine activity - TRAILR1 (TNFRSF10A): Receptor on plasma membrane raft with signaling receptor activity - ZDHHC3: Enzyme in Golgi apparatus that palmitoylates TRAILR1 - TRADD: Adaptor protein in cytoplasm with protein-macromolecule adaptor activity - FADD: Adaptor protein in cytoplasm with protein-macromolecule adaptor activity - CASP8: Caspase-8 with cysteine-type endopeptidase activity
Pathway flow: 1. TRAIL binds to TRAILR1 on the plasma membrane raft 2. TRAILR1 undergoes palmitoylation by ZDHHC3 in the Golgi apparatus 3. TRAILR1 activates TRADD in the cytoplasm 4. TRADD recruits FADD 5. FADD activates Caspase-8 (CASP8) 6. Caspase-8 triggers apoptosis via the TRAIL-activated apoptotic signaling pathway
All components and interactions are based on the GO-CAM model (gomodel:662af8fa00002877).
Feedback from AI on figure:
{"feedback":"The TRAIL/TRAILR1 pathway diagram effectively illustrates the molecular interactions leading to apoptosis with scientific accuracy and clarity. The diagram maintains a professional scientific journal style with appropriate color-coding and spatial organization.\n\nStrengths:\n- Clear representation of cellular compartments (extracellular space, plasma membrane raft, Golgi apparatus, cytoplasm)\n- Accurate depiction of protein interactions with directional arrows showing the pathway flow\n- Detailed labeling of molecular functions and GO terms\n- Appropriate use of colors to distinguish different types of proteins (cytokines, receptors, adaptors, caspases)\n- Well-organized legend explaining all visual elements\n- Professional typography suitable for scientific publication\n\nThe diagram accurately captures all components from the GO-CAM model while presenting them in a visually comprehensible manner that would be appropriate for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}