Figure: Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human)¶
This figure illustrates the regulation of TNF-alpha-mediated signaling pathway by TMC8 in human cells. The TNF ligand (P01375) in the extracellular space binds to and activates the TNFRSF1A receptor (P19438) at the cell membrane. Activated TNFRSF1A signals to the adaptor protein TRADD (Q15628) in the cytoplasm, which in turn activates TRAF2 (Q12933). TMC8 (Q8IU68) negatively regulates this pathway by sequestering TRADD, thereby inhibiting signal transduction. All these interactions are part of the TNF-mediated signaling pathway (GO:0033209), with TMC8's activity being specifically involved in the regulation of this pathway (GO:0010803). Proteins are depicted with their UniProt identifiers and molecular functions are labeled with Gene Ontology (GO) terms.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the TNF-alpha-mediated signaling pathway and TMC8's regulatory role in a visually appealing and scientifically accurate manner. The design achieves several key strengths: (1) Clear visual hierarchy that guides the viewer through the signaling cascade, (2) Effective use of color coding to distinguish different proteins and their functions, (3) Proper cellular context showing the membrane boundary and compartmentalization, (4) Inclusion of all relevant GO terms and protein identifiers without cluttering the diagram, (5) Strong contrast between activation and inhibition pathways, and (6) Professional legend that enhances interpretability. The diagram maintains the scientific accuracy of the GO-CAM model while presenting it in a visually engaging format suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}