Figure: Pyroptotic cell death mediated by GSDMD and NINJ1 (Human).¶
This diagram illustrates the pyroptotic cell death pathway mediated by GSDMD and NINJ1 in human cells. The pathway begins with CASP1 (caspase-1), which cleaves GSDMD (gasdermin D), leading to its activation. Active GSDMD binds to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol-4-phosphate (PI(4)P) in the plasma membrane, where it forms pores. Simultaneously, NINJ1 (Ninjurin-1) exerts membrane destabilizing activity at the plasma membrane. The combined actions of GSDMD pore formation and NINJ1-mediated membrane destabilization trigger pyroptotic cell death and positively regulate the inflammatory response.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the pyroptotic cell death pathway mediated by GSDMD and NINJ1 in human cells. The key components are clearly identified and their relationships well-established through appropriate visual connections. The use of color coding helps distinguish between different proteins and processes, while the added legend provides clear context for interpreting the diagram elements. The thicker causal relation arrows emphasize the main pathway flow, creating a clear visual hierarchy that guides the viewer through the sequence of events.","necessary_changes":null,"optional_changes":null}