Figure: TRAIL/TRAILR2 interaction leading to apoptosis¶
This figure illustrates the TRAIL/TRAILR2 apoptotic signaling pathway from the GO-CAM model (gomodel:663d668500001492). The pathway begins with TRAIL (TNFSF10) in the extracellular space, which exhibits cytokine activity (GO:0005125). TRAIL binds to TRAILR2 (TNFRSF10B) on the plasma membrane, which possesses signaling receptor activity (GO:0038023). Upon activation, TRAILR2 recruits the adaptor protein TRADD in the cytoplasm, which then recruits FADD. Both adaptor proteins function as protein-macromolecule adaptors (GO:0030674). Finally, FADD activates Caspase-8 (CASP8), which has cysteine-type endopeptidase activity (GO:0004197) and triggers the apoptotic process. The entire pathway is part of the TRAIL-activated apoptotic signaling pathway (GO:0036462) as defined in Gene Ontology.
Feedback from AI on figure:
{"feedback":"This illustration effectively captures the TRAIL/TRAILR2 apoptotic signaling pathway in a clear and scientifically accurate manner. The pathway is presented in a logical flow from extracellular TRAIL binding to the eventual activation of Caspase-8, with each protein and compartment clearly labeled. The use of distinctive colors helps distinguish different proteins, while the inclusion of GO terms provides valuable scientific context. The connection lines between proteins and their functions improve clarity, and the enlarged legend facilitates easy identification of pathway components. The overall style is appropriate for publication in high-impact journals like Cell or Nature, combining scientific accuracy with visual clarity.","necessary_changes":null,"optional_changes":null}