Figure: FASL-FAS interaction leading to apoptosis (human)¶
This diagram illustrates the FASL-FAS interaction pathway leading to apoptosis in humans. FASLG (P48023) in the extracellular space binds to FAS receptor (P25445) on the plasma membrane, activating signaling that recruits FADD (Q13158) in the cytoplasm. FADD functions as an adaptor to recruit and activate Caspase-8 (CASP8, Q14790), which exhibits cysteine-type endopeptidase activity, ultimately triggering extrinsic apoptotic signaling via death domain receptors. The numbered circles indicate the sequential steps of the pathway.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the FASL-FAS interaction pathway leading to apoptosis in human cells. The visualization clearly depicts the spatial organization and sequential steps of the signaling cascade. Each component is properly labeled with both its common name and UniProt identifier, and the cellular compartments (extracellular space, plasma membrane, cytoplasm) are clearly delineated. The addition of numbered sequence indicators enhances understanding of the pathway progression, making it ideal for publication in high-impact journals like Cell or Nature. The diagram is scientifically accurate while maintaining visual clarity, and the comprehensive legend provides necessary context for interpretation.","necessary_changes":null,"optional_changes":"The diagram could potentially be enhanced by indicating the oligomerization of FAS receptors that typically occurs upon FASL binding, or by showing the formation of the death-inducing signaling complex (DISC) more explicitly. However, these would be supplementary details beyond the core GO-CAM model provided."}