Figure: CD40-CD40L proximal activation of TRAF2 and TRAF5 (Human)¶
This diagram illustrates the CD40-CD40L proximal activation pathway leading to TRAF2 and TRAF5 activation in humans. The pathway begins with CD40LG (P29965) in the extracellular space exhibiting cytokine activity. CD40LG binds to CD40 (P25942) on the plasma membrane, which functions as a signaling receptor. This interaction subsequently activates TRAF2 (Q12933) and TRAF5 (O00463) in the cytoplasm, both of which exhibit ubiquitin protein ligase activity. All these components participate in the CD40 signaling pathway (GO:0023035). Arrows indicate the direction of signal flow, and labels describe the molecular functions associated with each protein.
Feedback from AI on figure:
{"feedback":"The final pathway diagram effectively illustrates the CD40-CD40L signaling cascade in a clear, scientifically accurate manner suitable for publication in journals like Cell or Nature. The diagram successfully captures all key components from the GO-CAM model while maintaining visual clarity. The use of distinctive colors, clear labels, and directional arrows makes the signal flow easy to follow. The addition of a comprehensive legend explains all components and their molecular functions, enhancing understanding for readers. The background boxes for function labels improve readability, and the cellular compartmentalization (extracellular space, plasma membrane, cytoplasm) accurately represents the biological context of each interaction in the pathway.","necessary_changes":null,"optional_changes":null}