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Figure: phosphatidylinositol phosphate/phosphatidylinositol/ biosynthetic process (GO:0006661)(GO:0043647)

id: gomodel:663d668500002178

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The diagram illustrates the phosphatidylinositol/inositol phosphate biosynthetic process in S. pombe, divided into two interconnected pathways:

  1. Phosphatidylinositol (PI) Pathway: External myo-inositol is imported across the plasma membrane by the itr2 transporter. Once inside the cell, pis1 converts myo-inositol to phosphatidylinositol (PI). PI is then phosphorylated by the stt4 kinase (with efr3 as an adaptor protein) to produce PI4P, which is further converted to PI(4,5)P2 by its3 kinase.

  2. Inositol Phosphate (IP) Pathway: PI(4,5)P2 is hydrolyzed by plc1 (phospholipase C) to generate IP3, the entry point to the inositol phosphate pathway. IP3 is sequentially phosphorylated by a series of kinases: arg82 converts IP3 to IP4, ipk1 converts IP4 to IP6, and finally kcs1 phosphorylates IP6 to produce IP7. Alternatively, IP6 can also be directly processed by asp1, while asp1 can also convert IP7 to IP8.

The color coding distinguishes myo-inositol (blue), phosphatidylinositol species (yellow), inositol phosphate species (red), and enzymes (green). The dashed line represents an alternative biochemical pathway.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the phosphatidylinositol/inositol phosphate biosynthetic process in S. pombe cells. The drawing is well-organized with clear separation between the two main pathways (phosphatidylinositol pathway and inositol phosphate pathway), helping readers understand the biochemical flow. The use of color coding for different types of molecules (myo-inositol, phosphatidylinositols, and inositol phosphates) and enzymes aids visual distinction. Enzyme functions are clearly labeled, and directional arrows effectively show the conversion processes. The inclusion of the plasma membrane helps contextualize the cellular location where these processes occur.","necessary_changes":null,"optional_changes":null}