Figure: canonical glycolysis (GO:0061621)¶
This figure illustrates the canonical glycolysis pathway in Schizosaccharomyces pombe (fission yeast), showing the sequential enzymatic reactions converting D-hexose (glucose) to pyruvate. The pathway occurs in the cytosol and involves ten key steps catalyzed by specific enzymes.
The pathway begins with two hexokinases (HXK1, HXK2) phosphorylating D-hexose to glucose-6-phosphate (G6P). This is followed by conversion to fructose-6-phosphate (F6P) by phosphoglucose isomerase (PGI1), and then to fructose-1,6-bisphosphate (F1,6BP) by phosphofructokinase (PFK1).
Aldolase (FBA1) splits F1,6BP into dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). Triose phosphate isomerase (TPI1) converts DHAP to G3P, resulting in two G3P molecules for the remaining steps.
The pathway continues with glyceraldehyde 3-phosphate dehydrogenase (TDH1, GPD3) converting G3P to 1,3-bisphosphoglycerate (1,3-BPG), followed by phosphoglycerate kinase (PGK1) producing 3-phosphoglycerate (3-PG). Phosphoglycerate mutase (GPM1) then generates 2-phosphoglycerate (2-PG).
The final stages involve enolase enzymes (ENO101, ENO102) converting 2-PG to phosphoenolpyruvate (PEP), and pyruvate kinase (PYK1) catalyzing the formation of pyruvate, the end product of glycolysis.
Feedback from AI on figure:
{"feedback":"The diagram provides a clear and comprehensive illustration of the canonical glycolysis pathway in S. pombe. The sequential arrangement of metabolites connected by enzymatic reactions creates an intuitive flow from top to bottom, making it easy to follow the biological process. \n\nThe color coding used for metabolites (orange), enzymes (green), and the final product (red) enhances visual clarity and helps distinguish between different components of the pathway. The consistent styling of elements throughout the diagram maintains visual cohesion.\n\nText labels are appropriately sized and positioned, with enzyme names prominently displayed along with their gene identifiers. The inclusion of a legend further improves the diagram's interpretability, making it suitable for publication in high-impact journals like Cell or Nature.\n\nThe figure successfully represents all the enzymes mentioned in the GO-CAM model, accurately capturing the pathway's progression from D-hexose (glucose) to pyruvate, with appropriate subcellular localization in the cytosol.","necessary_changes":null,"optional_changes":null}