Figure: TGFB1-mediated signaling pathway (Human)¶
This diagram illustrates the TGFB1-mediated signaling pathway in human cells as represented in the GO-CAM model (gomodel:663d668500003144). The pathway begins with TGFB1 cytokine in the extracellular space, which binds to and activates the type II TGF-β receptor (TGFBR2) at the plasma membrane. TGFBR2 then phosphorylates and activates the type I TGF-β receptor (TGFBR1). Activated TGFBR1 phosphorylates SMAD2 in the cytoplasm, which subsequently translocates to the nucleus where it functions as a transcription factor binding to DNA and regulating gene expression. The proteins shown (TGFB1, TGFBR2, TGFBR1, and SMAD2) are all present in the original GO-CAM model.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the TGFB1-mediated signaling pathway with clear visual hierarchy and organization across cellular compartments. The color-coding system establishes a visual language that helps readers track each component through the signaling cascade. All text elements are properly sized for readability, and the directional arrows clearly indicate the flow of signaling events from the extracellular space to the nucleus. The added 'Activated' label with directional arrow provides important context for SMAD2 phosphorylation, while the comprehensive legend helps readers understand the diagram's components. The cellular compartments are clearly delineated with consistent visual styling, making the subcellular localization of each component immediately apparent.","necessary_changes":null,"optional_changes":null}