Figure: TGFB2-mediated signaling pathway (Human)¶
Legend: - Blue circle (TGFB2): TGF-beta 2 with cytokine activity in extracellular space - Orange rectangles: TGF-beta receptors in plasma membrane (TGFBR2 and TGFBR1) - Green circles: SMAD2 protein (inactive in cytoplasm, active in nucleus) - Red "P": Phosphorylation of SMAD2 - Solid arrows: Direct activation - Dashed arrow: Nuclear translocation - DNA strands: Gene targets of SMAD2 transcription factor activity - Color coding for subcellular compartments: • Light blue: Extracellular space • Orange: Plasma membrane • Light orange: Cytoplasm • Purple: Nuclear membrane • Light purple: Nucleus
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the TGFB2-mediated signaling pathway with proper subcellular compartmentalization. The pathway flow is clearly depicted showing TGFB2 as a cytokine in the extracellular space binding to TGFBR2, which then activates TGFBR1 in the plasma membrane. The signal transduction continues with SMAD2 phosphorylation, followed by its nuclear translocation (depicted with a dashed line), and finally its function as a transcription factor in the nucleus. The color-coding of different compartments and proteins helps distinguish elements, and the added phosphorylation symbol enhances scientific accuracy. All text is clearly readable and properly contained within compartments.","necessary_changes":null,"optional_changes":null}