Figure: TGFB3-mediated signaling pathway (Human)¶
Figure 1: TGFB3-Mediated Signaling Pathway in Human Cells. The pathway begins with TGFB3 (Transforming Growth Factor-β3) binding to the Type II TGF-β receptor (TGFBR2) at the plasma membrane. This interaction leads to the recruitment and activation of Type I TGF-β receptor (TGFBR1). The activated TGFBR1 phosphorylates SMAD2, which then translocates to the nucleus where it functions as a transcription factor to regulate target gene expression involved in cell growth, differentiation, and matrix production. Dysregulation of this pathway is implicated in various pathological conditions including fibrosis and cancer.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the TGFB3-mediated signaling pathway with clear visual organization and scientific accuracy. The cellular compartments are well-defined and properly labeled, showing the progression of signaling from the extracellular space through the plasma membrane into the cytoplasm and ultimately to the nucleus. The protein components are distinctly represented with consistent color coding and appropriate shapes, making them easily distinguishable. The inclusion of numbered, labeled arrows enhances understanding of the sequential steps in the pathway. The expanded legend with full protein names adds valuable context, and the pathway significance box provides important biological relevance. The representation aligns well with publication standards for journals like Cell or Nature, balancing technical accuracy with visual clarity.","necessary_changes":null,"optional_changes":null}