Figure: tricarboxylic acid cycle (GO:0006099)¶
This diagram illustrates the tricarboxylic acid (TCA) cycle in S. pombe, showing the enzymes and metabolites involved in this central metabolic pathway. The cycle is depicted within a mitochondrion, with distinct compartmentalization between matrix-localized enzymes (green) and inner membrane-associated enzymes (purple).
Key features include: - All enzymes are labeled with their gene names from S. pombe - Metabolic intermediates are shown in yellow - The succinate dehydrogenase complex (sdh1/sdh2/sdh3/tim18) is specifically highlighted at the inner mitochondrial membrane - The α-ketoglutarate dehydrogenase complex shows the adaptor function of kgd4 - Redox reactions are indicated with cofactor conversions (NAD+→NADH, FAD→FADH2) - Acetyl-CoA (marked with asterisk) is shown as not being part of the original GO-CAM source
The diagram accurately represents the circular nature of the pathway, with reactions proceeding clockwise from citrate production through the oxidative steps of the cycle.
Feedback from AI on figure:
{"feedback":"The diagram successfully illustrates the tricarboxylic acid cycle in S. pombe with clear visual hierarchy and organization. The pathway is properly situated within the mitochondrial context, with appropriate differentiation between matrix enzymes and membrane-associated components. The enzymatic reactions flow logically in a circular pattern with directional arrows indicating the progression of the cycle. All gene products mentioned in the GO-CAM are accurately represented, and the inclusion of Acetyl-CoA (marked as not in the source) provides necessary context for understanding the cycle's entry point. The use of distinct colors for different components enhances readability, while consistent font styling improves overall clarity. The legend effectively explains the visual elements used in the diagram.","necessary_changes":null,"optional_changes":null}