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Figure: subtelomeric heterochromatin formation (GO:0031509)

id: gomodel:665912ed00001983

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This diagram depicts the molecular pathway of subtelomeric heterochromatin formation in Schizosaccharomyces pombe (fission yeast). The process involves coordinated actions of multiple protein complexes including:

  1. CLRC Complex: An E3 ubiquitin ligase complex including cul4, rik1, raf1, and raf2 that recruits histone modifiers.

  2. SHREC Complex: A histone deacetylase complex containing clr1, clr2, clr3, and mit1 that contributes to heterochromatin formation through deacetylation.

  3. RNAi Machinery: Includes dcr1, rdp1, hrr1, arb1, and ago1, which generate siRNAs that target regions for heterochromatin formation.

  4. RITS Complex: RNA-induced transcriptional silencing complex with chp1, tas3, and stc1 that directs the machinery to specific genomic regions.

  5. FACT Complex: Histone chaperone complex with pob3 and spt16 that facilitates heterochromatin assembly.

  6. Histone Modifiers: Key enzymes like clr4 (H3K9 methyltransferase) and heterochromatin proteins swi6 and chp2 that bind methylated histones.

  7. Histone Demethylases: lsd1 and lsd2 that modulate the methylation levels to regulate heterochromatin.

The arrows indicate causal relationships between components, with solid lines showing positive regulation and blue dashed lines showing regulatory modulation. The pathway ultimately leads to the formation of stable heterochromatin at subtelomeric regions, which is crucial for genome stability and silencing of repetitive elements.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the complex process of subtelomeric heterochromatin formation in S. pombe with clear visual organization. The use of color-coded protein complexes makes it easy to distinguish between the different functional groups, while the inclusion of gene identifiers maintains scientific accuracy.\n\nThe improvements in the final version include:\n1. More prominent and visually distinct arrow styles to differentiate between types of interactions\n2. Addition of labeled white background boxes for interaction descriptions, improving readability\n3. Inclusion of nucleosome illustrations in the telomere region to provide visual context\n4. A final outcome box highlighting the end result of heterochromatin formation\n5. Enhanced legend with clearer distinction between different regulatory mechanisms\n\nThese visual elements create a diagram that effectively balances scientific accuracy with visual clarity, making it suitable for publication in journals like Cell or Nature. The functional descriptions for each complex provide essential context without cluttering the main visualization.","necessary_changes":null,"optional_changes":null}