Figure: Angiopoietin-1-Thrombomodulin pair inhibiting Protein C activation (Human)¶
This diagram illustrates the Angiopoietin-1-Thrombomodulin pathway involved in the negative regulation of blood coagulation in humans.
Key components: - Angiopoietin-1 (ANGPT1): A ligand in the extracellular space that activates Thrombomodulin - Thrombomodulin (THBD): A receptor located in the plasma membrane - Thrombin (F2): An enzyme in the extracellular space with serine-type endopeptidase activity - Protein C (PROC): Another enzyme in the extracellular space with serine-type endopeptidase activity
The pathway shows that ANGPT1 positively regulates THBD (activation), which in turn inhibits Thrombin. Thrombin inhibits Protein C activation. Together, these interactions contribute to the negative regulation of blood coagulation (GO:0030195).
Green arrows indicate positive regulation (activation), while red dashed arrows indicate negative regulation (inhibition).
Feedback from AI on figure:
{"feedback":"The diagram effectively visualizes the Angiopoietin-1-Thrombomodulin pathway with clarity and scientific precision. The cellular compartments are clearly delineated with the extracellular space, plasma membrane, and cytoplasm distinctly labeled. The key molecular components—ANGPT1, THBD, Thrombin, and Protein C—are represented with appropriate shapes and colors, making them easily distinguishable. The regulatory relationships between these components are shown through well-designed arrows with clear directionality and accompanying text labels that explain the nature of each interaction (activation or inhibition). The inclusion of protein IDs and GO terms adds scientific rigor to the visualization, making it suitable for publication in high-quality journals. The legend effectively explains the symbols used, and the overall layout follows the conventions of scientific pathway diagrams.","necessary_changes":null,"optional_changes":null}