Figure: PF4-Thrombomodulin pair activating Protein C activation (Human)¶
This figure illustrates the PF4-Thrombomodulin pathway that activates Protein C in humans, leading to negative regulation of blood coagulation. In the extracellular space, PF4 (Platelet Factor 4, P02776) acts as a receptor ligand that positively regulates Thrombomodulin (THBD, P07204) on the plasma membrane. Thrombomodulin then negatively regulates Thrombin (F2, P00734) serine-type endopeptidase activity. Thrombin positively regulates Protein C (PROC, P04070) activation. The activated Protein C (APC) is the functional entity that contributes to negative regulation of blood coagulation. Green arrows indicate positive regulation, red arrows indicate negative regulation, and dashed gray arrows represent implicit relationships not explicitly stated in the source GO-CAM.
Feedback from AI on figure:
{"feedback":"The revised SVG drawing clearly depicts the PF4-Thrombomodulin pathway activating Protein C in humans. The diagram effectively uses compartmentalization to distinguish between extracellular space, plasma membrane, and cytoplasm. Each protein is appropriately labeled with both common names and UniProt identifiers, and their molecular functions are clearly indicated. The use of colored arrows with consistent markers helps distinguish between positive and negative regulation, while dashed lines indicate implicit relationships not explicitly in the source data. The addition of a legend enhances interpretability, and background colors for text labels improve readability. The overall layout follows conventional scientific illustration standards suitable for publication in journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}