Figure: CD93/Multimerin-2/β1 integrin complex function in angiogenesis (Human)¶
This figure illustrates the CD93/Multimerin-2/β1 integrin complex function in angiogenesis in human endothelial cells. Multimerin-2 (MMRN2, depicted as a red circle) in the extracellular space exhibits receptor ligand activity and interacts with CD93 (blue rectangle) on the plasma membrane, which functions as a signaling receptor. CD93 then interacts with β1 integrin (ITGB1, green rectangle), which has coreceptor activity. Together, these molecular interactions contribute to the angiogenesis process. Solid arrows indicate direct causal relationships between proteins, while dashed arrows show participation in the biological process of angiogenesis.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the GO-CAM model of CD93/Multimerin-2/β1 integrin complex function in angiogenesis. The drawing clearly shows the spatial relationships between components (extracellular vs. membrane-bound), their molecular functions, and how they contribute to angiogenesis. The color coding and shapes consistently differentiate between the proteins and their activities, while the arrows clearly indicate the causal relationships. The comprehensive legend explains all visual elements, making this suitable for publication in a high-impact journal. The text size has been increased from previous versions to ensure readability when printed or projected.","necessary_changes":null,"optional_changes":null}