Figure: Thrombin-Thrombomodulin pair activating Protein C activation (Human)¶
The diagram illustrates the pathway by which Thrombin (F2) and Thrombomodulin (THBD) activate Protein C (PROC) to negatively regulate blood coagulation in humans.
Key components: - F2 (Thrombin): A serine protease with receptor ligand activity - THBD (Thrombomodulin): A transmembrane receptor on the plasma membrane - PROC (Protein C): A zymogen that is activated to inhibit coagulation
Interactions: 1. Thrombin acts as a ligand for Thrombomodulin receptor (red arrow) 2. Thrombomodulin positively regulates Thrombin's activity (green arrow) 3. Thrombin acts as a serine-type endopeptidase on Protein C (blue arrow) 4. Protein C becomes activated (purple arrow) 5. Activated Protein C contributes to negative regulation of blood coagulation (orange arrow)
This pathway is critical for preventing excessive clotting by inactivating coagulation factors V and VIII.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the Thrombin-Thrombomodulin pathway for Protein C activation in a style suitable for a scientific journal. The representation clearly shows the spatial organization (extracellular space vs. plasma membrane) and the sequential interactions between proteins.\n\nThe diagram has several strengths:\n1. Clear visual distinction between proteins using different shapes and colors\n2. Well-labeled interactions with color-coded arrows that indicate different types of molecular activities\n3. Comprehensive legend that explains both proteins and interaction types\n4. Professional appearance with appropriate spacing and layout\n5. Improved text readability with larger font sizes and background fills to prevent text overlap\n\nThe combination of precise molecular details and clear visual organization makes this diagram immediately understandable to scientific audiences while maintaining the accuracy of the underlying GO-CAM model.","necessary_changes":null,"optional_changes":null}