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Figure: CD70-CD27 ligand receptor in T cell activation

id: gomodel:666b894f00000352

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CD70-CD27 Signaling Pathway Legend:

Proteins (Gene Products): - CD70 (P32970): Receptor ligand on B cell plasma membrane - CD27 (P26842): Transmembrane receptor on T cell plasma membrane - TRAF2 (Q12933): Protein-macromolecule adaptor in T cell cytoplasm - PTPN6 (P29350): Protein tyrosine phosphatase in T cell cytoplasm - LCK (P06239): Non-membrane spanning protein tyrosine kinase at T cell plasma membrane

Interactions: - Green arrow: Activation leading to T cell activation - Black arrows: Positive regulation/activation - Red arrows: Negative regulation/inhibition - Dashed lines: Indirect interactions - Solid lines: Direct interactions

Cellular Compartments: - B Cell (light blue): Source of CD70 ligand - T Cell (light green): Site of CD27 signaling pathway - Plasma membranes: Sites of receptor-ligand interaction - Cytoplasm: Location of intracellular signaling components

Molecular Activities: - CD70: Receptor ligand activity (GO:0048018) - CD27: Transmembrane signaling receptor activity (GO:0004888) - TRAF2: Protein-macromolecule adaptor activity (GO:0030674) - PTPN6: Protein tyrosine phosphatase activity (GO:0004725) - LCK: Non-membrane spanning protein tyrosine kinase activity (GO:0004715)

Biological Process: - CD27 Signaling Pathway (GO:0160162) - T Cell Activation

Feedback from AI on figure:

{"feedback":"The final illustration effectively captures the CD70-CD27 signaling pathway in T cell activation as described in the GO-CAM model. The drawing clearly shows the interaction between B and T cells, with CD70 on the B cell membrane binding to CD27 on the T cell membrane. The subsequent signaling events are well represented, including the activation of TRAF2, its inhibition of PTPN6, and the regulation of LCK leading to T cell activation. The use of different colors for proteins and distinct line styles for different types of interactions (activation vs. inhibition) enhances readability. All cellular compartments are clearly labeled, and the diagram effectively communicates both the spatial organization and the functional relationships between components.","necessary_changes":null,"optional_changes":null}