Figure: ROR1 activation by IGFB5 leading to cell proliferation (Human)¶
This figure illustrates the ROR1 activation pathway by IGFBP5 leading to cell proliferation in humans (GO-CAM model: 666b894f00002484). The signaling cascade begins in the extracellular space where IGFBP5 (receptor ligand) activates ROR1 (signaling receptor) at the plasma membrane. Activated ROR1 then triggers ERBB2 (protein tyrosine kinase), also at the plasma membrane. ERBB2 signaling ultimately activates CREB1 (DNA-binding transcription activator, RNA polymerase II-specific) in the nucleus, which drives the expression of genes involved in cell proliferation. Each protein is shown in its proper cellular compartment based on GO annotations: IGFBP5 in extracellular space (GO:0005615), ROR1 and ERBB2 at the plasma membrane (GO:0005886), and CREB1 in the nucleus (GO:0005634). The diagram depicts a simplified version of the pathway focusing on the key molecular players and their causal relationships.
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{"feedback":"This diagram effectively illustrates the ROR1 activation pathway leading to cell proliferation in a clean, journal-ready format. The cellular compartments are clearly delineated and labeled (extracellular space, plasma membrane, cytoplasm, and nucleus), with each protein accurately positioned within its correct subcellular location. The signaling flow from IGFBP5 to ROR1 to ERBB2 to CREB1, ultimately leading to cell proliferation, is clearly indicated with directional arrows and activation labels. The protein representations are consistent and easily distinguishable with a helpful legend explaining the color-coding system. The improved font sizes ensure all text is readable, and the centered alignment of function labels provides a clean, professional appearance. The title effectively summarizes the biological process being illustrated, making this suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}