Figure: CD48-CD244 ligand receptor binding in NK cell activation¶
This figure illustrates the CD48-CD244 ligand-receptor binding pathway in Natural Killer (NK) cell activation in humans. CD48 (P09326) on the adjacent cell binds to CD244 (Q9BZW8) on the NK cell membrane raft. This binding initiates a signaling cascade where: (1) CD244 recruits the adaptor protein SH2D1A (O60880) in the cytoplasm; (2) SH2D1A engages the tyrosine kinase FYN (P06241); (3) FYN phosphorylates and activates VAV1 (P15498), a guanyl-nucleotide exchange factor; (4) VAV1 activation leads to NK cell activation. Additionally, FYN provides feedback (5) to CD244, amplifying the signaling pathway. Different protein types are represented by distinct shapes: rectangles for receptors and GEF, ellipses for adaptors, and diamonds for kinases.
Feedback from AI on figure:
{"feedback":"The figure clearly illustrates the CD48-CD244 ligand-receptor binding pathway in NK cell activation, using appropriate shapes and colors to distinguish different protein types. The spatial organization effectively shows the compartmentalization of the signaling pathway, with membrane raft localization of key components clearly depicted. Text labels are properly sized and positioned for optimal readability, and the numbered pathway steps help guide viewers through the signaling cascade. The feedback loop from FYN to CD244 is now more explicitly marked, enhancing understanding of this regulatory mechanism. The overall composition follows standard conventions for scientific journal figures, making it suitable for publications like Cell or Nature.","necessary_changes":null,"optional_changes":null}