Figure: Androgen biosynthesis 1 (Mouse)¶
This figure illustrates the androgen biosynthesis pathway in mouse as represented in the GO-CAM model. The pathway shows the enzymatic conversions from pregnenolone to testosterone and dihydrotestosterone (DHT) occurring in the endoplasmic reticulum membrane.
Key enzymes in this pathway include Cyp17a1 (steroid 17-alpha-monooxygenase), which catalyzes the conversion of pregnenolone to 17α-hydroxypregnenolone and subsequently to DHEA (dehydroepiandrosterone), as well as progesterone to 17α-hydroxyprogesterone. Hsd3b1 (steroid delta-isomerase) converts pregnenolone to progesterone and DHEA to androstenedione. Hsd17b3 (testosterone dehydrogenase) transforms androstenedione to testosterone. Finally, Srd5a1 and Srd5a2 (3-oxo-5-alpha-steroid 4-dehydrogenase) convert testosterone to dihydrotestosterone (DHT).
The cofactors NADPH, NAD+, and O₂ are essential for these enzymatic reactions. All reactions shown occur in the endoplasmic reticulum membrane (GO:0005789) as part of the androgen biosynthetic process (GO:0006702).
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the androgen biosynthesis pathway in mice with excellent clarity and scientific accuracy. The use of distinct visual elements for different components - orange circles for steroid molecules, pink rectangles for enzymes, and white rectangles with borders for cofactors - creates a clear visual hierarchy that is easy to interpret. The simplified representation of the ER membrane helps maintain focus on the pathway elements while providing necessary cellular context. The increased font sizes and bold text enhance readability for key molecules and enzymes. The clear organization of the pathway, with proper spacing between elements and logical flow of reactions, makes the biological process easy to follow. The comprehensive legend and additional information about the key enzymes provide valuable context for readers unfamiliar with androgen biosynthesis. This illustration would be suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}