Figure: Androgen biosynthetic process 2 (Mouse)¶
The figure depicts the androgen biosynthetic pathway in mouse, showing the sequential enzymatic reactions that convert pregn-5-ene-3,20-dione into androstane-3α,17β-diol. The pathway begins in the endoplasmic reticulum with the conversion of pregn-5-ene-3,20-dione to progesterone by Hsd3b1 (steroid delta-isomerase). Cyp17a1 (steroid 17α-monooxygenase) catalyzes two consecutive reactions, first converting progesterone to 17α-hydroxyprogesterone and then to androst-4-ene-3,17-dione. Hsd17b3 (testosterone dehydrogenase) transforms androst-4-ene-3,17-dione to testosterone, which can be further metabolized by either Srd5a1 or Srd5a2 (3-oxo-5-alpha-steroid 4-dehydrogenases) to produce 17β-hydroxy-5α-androstan-3-one. The final reaction occurs in the cytosol, where Akr1c14 (steroid dehydrogenase) converts 17β-hydroxy-5α-androstan-3-one to androstane-3α,17β-diol. All enzymatic reactions utilize NADPH as a cofactor (except the final reaction which uses NADP+), along with other cofactors including H+, O2, and H2O, as indicated in the small boxes adjacent to each enzyme. The diagram is consistent with the gene ontology-based cellular annotation model (GO-CAM) of androgen biosynthesis in mouse.
Feedback from AI on figure:
{"feedback":"The drawing is exceptionally well-structured and clearly illustrates the androgen biosynthetic pathway in mouse. The clarity is excellent, with distinct compartmentalization showing the endoplasmic reticulum and cytosol as different colored regions with appropriate membrane structures. The pathway flow is logically presented with bold arrows clearly indicating the direction of reactions.\n\nEach enzyme (Hsd3b1, Cyp17a1, Hsd17b3, Srd5a1, Srd5a2, and Akr1c14) is clearly labeled with its corresponding molecular function, adding educational value to the figure. The metabolites are presented in well-defined ellipses with both common names and chemical identifiers.\n\nThe color-coding of cofactors (particularly NADPH/NADP+) enhances readability, and the cofactor boxes adjacent to each enzyme provide clear information about reaction requirements. The legend is concise yet comprehensive, allowing readers to quickly understand the diagram's components.\n\nThis illustration is publication-ready for journals like Cell or Nature, combining scientific accuracy with aesthetic appeal that effectively communicates the complex metabolic pathway.","necessary_changes":null,"optional_changes":null}