Skip to content

Figure: arginine biosynthesis

id: gomodel:6690711d00000916

img

Legend for the Arginine Biosynthesis Pathway:

Numbered Enzyme Steps and Functions: 1. arg6 (SPBC725.14) - L-glutamate N-acetyltransferase: Catalyzes the formation of N-acetylglutamate from L-glutamate 2. arg11 (SPAC4G9.09c) - Functions as both acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase 3. arg1 (SPCC777.09c) - N2-acetyl-L-ornithine aminotransferase: Converts N-acetylglutamate semialdehyde to N-acetylornithine 4. aga1 (SPBC1271.14) - Glutamate N-acetyltransferase: Involved in processing N-acetylornithine 5. arg3 (SPAC4G9.10) - Ornithine carbamoyltransferase: Converts L-ornithine to citrulline 6. Transporter (not explicitly in source data): Transports citrulline from mitochondria to cytosol 7. arg12 (SPBC428.05c) - Argininosuccinate synthase: Forms argininosuccinate in the cytosol 8. arg7 (SPBC1773.14) - Argininosuccinate lyase: Converts argininosuccinate to arginine 9. arg41 (SPBC1539.03c) - Argininosuccinate lyase: Alternative enzyme for converting argininosuccinate to arginine

Compartments: - Mitochondrion (orange outline): Early steps of arginine biosynthesis occur here - Cytosol (outer cell area): Final steps of arginine biosynthesis occur here

Key Metabolites: - L-glutamate (CHEBI:29985): Starting substrate - N-acetylglutamate (CHEBI:57805): First intermediate - N-acetylornithine (CHEBI:16543): Precursor to ornithine - L-ornithine (CHEBI:15729): Key intermediate in mitochondria - Citrulline: Exported from mitochondria to cytosol - Argininosuccinate: Cytosolic intermediate - Arginine (CHEBI:29016): Final product

Special Feature: This diagram highlights that S. pombe exports citrulline from mitochondria to cytosol, which differs from S. cerevisiae that exports ornithine instead.

Feedback from AI on figure:

{"feedback":"This scientific illustration effectively captures the arginine biosynthesis pathway in S. pombe with professional visual clarity suitable for publication in high-impact journals like Cell or Nature. The pathway is accurately represented with clear compartmentalization between mitochondrial and cytosolic processes, using appropriate color coding that enhances visual distinction between different components.\n\nThe numbered reaction steps provide an intuitive flow through the pathway, and the inclusion of gene identifiers and CHEBI codes adds scientific rigor. The enhanced contrast between components and improved text readability makes all elements clearly visible. The addition of enzyme functions for each numbered step provides valuable context without cluttering the main diagram.\n\nThe legend is comprehensive and well-organized, making the figure self-explanatory even to readers not deeply familiar with arginine metabolism. The note about S. pombe exporting citrulline rather than ornithine (unlike S. cerevisiae) highlights an important biological distinction that was specified in the source data.","necessary_changes":null,"optional_changes":null}