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Figure: Protein O-linked glycosylation 1 (Mouse)

id: gomodel:6690711d00001433

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The diagram illustrates the protein O-linked glycosylation pathway in mice, showing four key enzymatic reactions occurring at the endoplasmic reticulum membrane. Key components include:

  1. Enzymes (colored rectangles):
  2. POMT1/POMT2 complex (red): Transfers mannose from dolichyl D-mannosyl phosphate
  3. POMGNT2 (green): Adds N-acetylglucosamine
  4. B3GALNT2 (blue): Adds N-acetylgalactosamine

  5. POMK (yellow): Phosphorylates the glycan structure

  6. Substrates (blue circles):

  7. Dolichyl D-mannosyl phosphate
  8. UDP-N-acetyl-glucosamine
  9. UDP-N-acetyl-galactosamine

  10. ATP

  11. Products (beige circles):

  12. Dolichyl phosphate
  13. UDP (produced twice)

  14. ADP

  15. Glycan components (small colored circles):

  16. M: Mannose
  17. G: N-acetylglucosamine
  18. Ga: N-acetylgalactosamine

  19. P: Phosphate group

  20. DAG1 (dystroglycan) is shown as the implied target protein but is not explicitly mentioned in the source GO-CAM.

Feedback from AI on figure:

{"feedback":"The final diagram effectively illustrates the protein O-linked glycosylation pathway in mouse with excellent clarity and scientific accuracy. The visualization includes clear delineation of the ER membrane compartment, properly labeled enzymes with their functions, appropriate substrates and products for each reaction, and a logical flow of the pathway. The addition of detailed enzyme function descriptions within each enzyme box and the supplementary reaction descriptions enhance understanding. The glycan component coding adds valuable information about the building blocks being added in the pathway. The color coding is consistent and helps differentiate between different components, with a comprehensive legend that explains all elements of the diagram. The artistic style would be appropriate for publication in scientific journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}