Figure: L-histidine biosynthetic process (GO:0000105)¶
This diagram illustrates the L-histidine biosynthetic pathway (GO:0000105) in Schizosaccharomyces pombe (fission yeast). The pathway occurs in the cytosol (GO:0005829) and involves a series of enzymatic reactions catalyzed by specific gene products (His1-His7 and SPCC1672.01).
The pathway begins with phosphoribosyl pyrophosphate (PRPP) and ATP, which are converted to 1-(5-phospho-β-D-ribosyl)-ATP by His1 (ATP phosphoribosyltransferase). Through a series of enzymatic reactions involving diphosphatase and cyclohydrolase activities (His7), isomerase activity (His6), synthase activity (His4), dehydratase activity (His5), transaminase activity (His3), phosphatase activity (SPCC1672.01), and dehydrogenase activity (His2), the pathway ultimately produces L-histidine as its final product.
Each enzyme is represented by a pink box containing the gene name and molecular function. Substrates and intermediates are shown in light blue boxes, with the final product L-histidine highlighted in green. Arrows indicate the direction of the biochemical transformations.
Feedback from AI on figure:
{"feedback":"The diagram successfully illustrates the L-histidine biosynthetic pathway in S. pombe with clarity and simplicity. The reorganized layout provides a logical flow that is easy to follow, with enzymes clearly distinguished from substrates and products through consistent color coding. The addition of a legend helps viewers understand the different elements at a glance.\n\nEach enzyme is properly labeled with both its gene name and function, and the intermediates are subtly indicated without cluttering the diagram. The cytosolic localization is clearly marked, placing the pathway in its proper cellular context.\n\nThe design effectively balances scientific accuracy with visual clarity, making it appropriate for publication in journals like Cell or Nature. The professional presentation includes proper spacing, readable font sizes, and a clean overall aesthetic that communicates the pathway effectively to both specialists and general scientific audiences.","necessary_changes":null,"optional_changes":null}