Figure: IGF1-mediated signaling via IGF1R receptor (Human)¶
This figure illustrates the IGF1-mediated signaling pathway via the IGF1R receptor in human cells. The pathway begins with IGF1 (Insulin-like Growth Factor 1, P05019) in the extracellular space, which binds to its receptor IGF1R (P08069) on the plasma membrane. This binding activates the receptor's signaling function, leading to the recruitment and activation of two key signaling adaptors in the cytoplasm: IRS1 (Insulin Receptor Substrate 1, P35568) and IRS2 (Insulin Receptor Substrate 2, Q9Y4H2). Both adaptors participate in transmitting the IGF1 signal within the cell, contributing to the insulin-like growth factor receptor signaling pathway (GO:0048009). Cellular compartments are color-coded: extracellular space (light blue), plasma membrane (orange), and cytoplasm (light green). Arrows indicate the direction of signal flow and activation events.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the IGF1-mediated signaling pathway in human cells with excellent scientific accuracy and visual clarity. The cellular compartments are clearly delineated and labeled with their GO terms, making the spatial organization immediately apparent. Each protein is represented with its common name, UniProt identifier, and associated molecular function, providing comprehensive information about the pathway components. The directional flow of the signaling cascade is clearly indicated with bold arrows and descriptive labels for the interactions. The use of distinct colors for different cellular compartments and protein types enhances visual discrimination while maintaining a professional appearance suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}