Figure: IGF2-mediated signaling via IGF1R receptor (Human)¶
Legend: • Cellular Compartments: - Light Blue: Extracellular Space (GO:0005615) - Blue: Plasma Membrane (GO:0005886) - Light Orange: Cytoplasm (GO:0005737)
• Proteins: - Orange Circle: IGF2 (P01344) - Growth factor - Blue Rectangle: IGF1R (P08069) - Receptor protein - Green Rectangles: IRS1 (P35568) and IRS2 (Q9Y4H2) - Adaptor proteins
• White Rounded Rectangles: Molecular Function annotations
• Arrows: Direction of signaling cascade
• Pink Rounded Rectangle: Overall biological process
The diagram depicts the insulin-like growth factor signaling pathway where IGF2 in the extracellular space binds to IGF1R on the plasma membrane, which then activates the downstream adaptor proteins IRS1 and IRS2 in the cytoplasm.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the IGF2-mediated signaling pathway via IGF1R receptor. It clearly distinguishes between the different cellular compartments (extracellular space, plasma membrane, and cytoplasm) using distinct colors. The proteins involved are well-labeled with their respective activity and GO terms. The flow from IGF2 to IGF1R and then downstream to IRS1 and IRS2 is direct and clear, effectively demonstrating the signaling pathway. The inclusion of activity types and relevant GO annotations adds to the informative nature of the diagram.","necessary_changes":null,"optional_changes":null}