Figure: Thrombopoeitin-mediated signaling pathway (Human)¶
This figure illustrates the Thrombopoietin-mediated signaling pathway in humans based on the GO-CAM model (gomodel:66a3e0bb00002890). The signaling cascade begins with Thrombopoietin (THPO, P40225) in the extracellular space exerting its cytokine activity to activate the Thrombopoietin receptor (MPL, P40238) located in the plasma membrane. This activation triggers the protein tyrosine kinase activity of JAK2 (O60674) in the cytoplasm, which subsequently leads to the activation of STAT5A (P42229). Activated STAT5A translocates to the nucleus where it acts as a DNA-binding transcription factor to regulate gene expression. The pathway components are shown in their respective cellular compartments: extracellular space, plasma membrane, cytoplasm, and nucleus.
Feedback from AI on figure:
{"feedback":"The diagram clearly illustrates the Thrombopoietin-mediated signaling pathway in humans. It accurately represents the four key proteins (THPO, MPL, JAK2, and STAT5A) in their correct cellular compartments with proper visual organization. The pathway flow is logically presented with directional arrows and descriptive labels for each step in the signaling cascade. The addition of a legend enhances understanding by explaining the color scheme and shapes used for different protein types. The diagram effectively balances scientific accuracy with visual clarity, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}