Figure: PVR-CD226 mediated NK-cell cytotoxicity (Human)¶
This figure illustrates the PVR-CD226 mediated NK-cell cytotoxicity pathway in humans. The diagram shows the interaction between a target cell (left) and a Natural Killer (NK) cell (right). On the target cell plasma membrane, PVR (P15151) acts as a receptor ligand that binds to CD226 (Q15762) on the NK cell plasma membrane. This interaction initiates a signaling cascade where CD226 activates GRB2 (P62993) in the NK cell cytoplasm, which functions as a protein-macromolecule adaptor. GRB2 then activates VAV1 (P15498), a guanyl-nucleotide exchange factor, also in the NK cell cytoplasm. This signaling pathway contributes to natural killer cell mediated cytotoxicity (GO:0042267), a process by which NK cells recognize and eliminate target cells.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the PVR-CD226 mediated NK-cell cytotoxicity pathway described in the GO-CAM model. The use of distinct colors for the target cell and NK cell creates clear spatial separation, while the labeled proteins and their activities are shown in their appropriate cellular compartments. The enhanced green arrows with increased thickness make the signaling cascade more visually prominent, and the purple colored molecular function labels provide better visual distinction from the protein names. The legend provides a comprehensive explanation of the pathway components and their interactions.","necessary_changes":null,"optional_changes":null}