Figure: AKT1 inhibits EIF2AK3/PERK (Human).¶
This diagram illustrates the AKT1 inhibition of the PERK-mediated unfolded protein response pathway in human cells. The pathway shows how AKT1 (P31749) inhibits EIF2AK3/PERK (Q9NZJ5) located in the endoplasmic reticulum membrane, which normally phosphorylates eIF2α (P05198) in the cytosol during ER stress. When phosphorylated, eIF2α activates ATF4 (P18848), a transcription factor that translocates to the nucleus to regulate gene expression during the unfolded protein response. Different cellular compartments are distinguished by colors: cytosol (light blue), nucleus (light green), and ER membrane (light red). Proteins are represented by different shapes and colors: AKT1 (orange circle), PERK (red rectangle), eIF2α (blue rectangle), and ATF4 (green rectangle). Arrows indicate molecular interactions: black arrows represent activation, while red arrows indicate inhibition.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the key elements of the pathway, displaying a clear visual representation of how AKT1 inhibits EIF2AK3/PERK. The compartments are correctly labeled, with distinct areas for the cytosol, nucleus, and endoplasmic reticulum membrane. Proteins are marked with different colors and shapes, enhancing readability, and the pathways are depicted through arrows that indicate interactions and regulations clearly. The improved font sizes make all text elements more readable, and the additional process labels provide context for the molecular functions involved. The diagram successfully captures the essential components and relationships in the GO-CAM model in a style suitable for a scientific journal.","necessary_changes":null,"optional_changes":null}