Figure: PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human)¶
This diagram illustrates the PVR-TIGIT signaling pathway that negatively regulates NK cell-mediated cytotoxicity.
Key components: - PVR (P15151): Expressed on target cells, functions as a receptor ligand - TIGIT (Q495A1): Expressed on NK cells, functions as a signaling receptor - GRB2 (P62993): Adaptor protein in NK cell cytoplasm - INPP5D (Q92835): Phosphatase in NK cell cytoplasm - PIK3CB (P42338): Kinase involved in NK cell cytotoxicity
The pathway shows how PVR on target cells binds to TIGIT on NK cells, triggering a signaling cascade: TIGIT activates GRB2, which activates INPP5D. INPP5D inhibits PIK3CB, which normally promotes NK cell-mediated cytotoxicity. This cascade results in the negative regulation of NK cell cytotoxicity, preventing the NK cell from killing the target cell.
Color coding and arrows indicate protein types and interaction mechanisms (activation vs. inhibition) as shown in the legend.
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively illustrates the PVR-TIGIT interaction and its role in inhibiting NK cell-mediated cytotoxicity. The design is clear, with appropriate use of color coding, shapes, and directional arrows to indicate different proteins and interaction types. The cellular compartments are well-defined, showing target and NK cells with labeled plasma membranes and cytoplasm. All proteins are clearly labeled with both their names and UniProt IDs, making the diagram scientifically accurate and precise. The legend provides excellent context for understanding the color scheme and interaction types. The increased font size in the final version enhances readability, making this suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}