Figure: GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human).¶
This diagram illustrates the GRM1-GNAQ-GRID2 signaling pathway in Purkinje cells. The pathway begins with glutamate binding to GRM1 receptors at the postsynaptic density membrane, activating GNAQ (G protein). GNAQ then activates PLCB3 (phospholipase C), which produces secondary messengers DAG and IP3. DAG, together with calcium (shown as an implicit factor not explicitly mentioned in the source data), activates PRKCG (protein kinase C), which subsequently phosphorylates and activates GRID2 ion channels. This signaling cascade is part of the synaptic signaling via neuropeptide biological process.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the GRM1-GNAQ-GRID2 signaling pathway in Purkinje cells as described in the GO-CAM model. The layout clearly shows the spatial organization of the pathway components from the synaptic cleft through the postsynaptic density membrane and into the postsynaptic cytosol. Each protein is appropriately labeled with both its common name and UniProt identifier, and their molecular activities are indicated. The flow of the pathway is well-represented with directional arrows and explanatory text for each step in the signaling cascade.","necessary_changes":null,"optional_changes":"While the diagram is already clear and comprehensive, future iterations could consider adding more contextual information about the physiological role of this pathway in Purkinje cell function, or including representations of the specific phosphorylation sites on GRID2 that are modified by PRKCG, if such information becomes available."}