Figure: ICOSLG-ICOS pair activates T follicular helper cell differentiation (Human)¶
This diagram illustrates the ICOSLG-ICOS signaling pathway leading to T follicular helper (Tfh) cell differentiation in humans. ICOSLG (O75144) on the plasma membrane of an antigen-presenting cell binds to the ICOS receptor (Q9Y6W8) on the T cell surface. This interaction triggers downstream signaling through TBK1 (Q9UHD2, a serine/threonine kinase) and PIK3R1 (P27986, a phosphatidylinositol 3-kinase regulator) in the T cell cytoplasm. These signals work together to promote T follicular helper cell differentiation, which is essential for B cell help and antibody responses.
Feedback from AI on figure:
{"feedback":"The final drawing effectively illustrates the ICOSLG-ICOS interaction pathway promoting T follicular helper cell differentiation. The diagram clearly shows the interaction between the antigen-presenting cell and T cell, with well-labeled proteins and cellular compartments. The addition of pathway step labels clarifies the signaling process, and the use of different arrow weights helps emphasize the main pathway. The color coding and comprehensive legend make the diagram suitable for a professional scientific publication.","necessary_changes":null,"optional_changes":null}