Figure: GRIM1 activates GRID1 via GNAQ in dopamine neurons (Mouse).¶
This figure illustrates the signaling pathway where GRM1 (Grm1, metabotropic glutamate receptor) activates GRID1 (Grid1, glutamate receptor) via GNAQ (Gnaq, G protein) in dopaminergic neurons. The pathway begins when glutamate binds to GRM1 in the postsynaptic density membrane, activating the G protein GNAQ in the postsynaptic cytosol. GNAQ subsequently activates PLCB3 (Plcb3, phospholipase C beta 3), which hydrolyzes PIP2 into the second messengers IP3 and DAG. DAG then activates PRKCG (Prkcg, protein kinase C gamma), which ultimately leads to the activation of GRID1 receptors in the postsynaptic density membrane. This signaling cascade is part of the phospholipase C-activating G protein-coupled receptor signaling pathway in dopaminergic neurons.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the GRM1-GRID1 signaling pathway in dopaminergic neurons with excellent clarity and organization. The cellular compartmentalization is well-represented, showing distinct regions for the synaptic cleft, postsynaptic density membrane, and postsynaptic cytosol. Each protein and molecule is depicted with a unique shape and color, making them easily distinguishable, while arrows clearly indicate the direction and sequence of activation steps. The addition of numbered step annotations provides helpful context for understanding the pathway progression. The color-coding system and comprehensive legend enhance the diagram's interpretability, making it appropriate for publication in high-impact journals like Cell or Nature. All text is clearly readable and positioned to avoid overlap with other elements.","necessary_changes":null,"optional_changes":null}